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 List of Appropriate Porcine Enzymes for an EPI dogs (or cat) in alphabetic order:

Sept 2022 Revised & work in progress updated list:

Enzyme powder with approx
Std 71,400 USP units of Lipase, 388,000 USP units Protease, 460,000 USP units Amylase
High Potency Enzyme powder with approx 110,000 USP units of Lipase, etc Enzyme pills/capsules (some with lesser potency) multiple pills needed Enteric coated Enzymes Raw enzymes
Biocase (discontinued) EnzymeDiane 8x Chemeyes CREON
EnzymeDiane 6x Enzymax Tablets Cotazym GreenTripe Raw Beef Pancreas
EpiZyme Pancrea Plus Lypex Hare Today
Panakare Plus Pancrea Tabs Plus Pancrealipase Raw To Go
Pancreatic Enzyme Concentrate Pancreoflat Pancrex
Pancrezyme Protexin
PancrePlus WeNzymes
Pet-Zyme 10x

For additional information on the above appropriate listed enzymes….. please see below:

BIOCASE V made by Thomas Labs, 800-359-8387.  Unfortunately these enzymes  are being discontinued

CHEMEYES  porcine pancreatin powder for Uk members  at very reasonable rates. Visit the and/or contact the proprietor, Cameron,  directly at [email protected] (see below for a full description)

CREON (available world-wide!!!!)

CREON is enteric coated microspheres of enzymes encased in capsules. These capsules may be given whole or sprinkled on food if served immediately. Alternately, some people find that after giving Creon waiting for approximately 5 minutes before feeding is more effective. Every dog is different and experimentation is required to find the most effective method. Please note: if you are going to sprinkle the contents ensure that the dog eats the entire meal so that all of the Creon is ingested. If in doubt, give the capsule whole before trying the sprinkling method.

CREON is commonly used in many places outside the U.S.  Existing CREON enzyme capsule products vary from region to region with not all strengths available in all regions. They can come in 5 , 6, 10, 12, 25, 40 strengths and new strengths approved as of 2009 of 6, 12, strengths are becoming more readily available mainly in the US.  Because the enzymes in CREON is enteric coated- -the recommended enzyme potency to treat EPI is dramatically different from pancreatin powder or pills! When initially treating an EPI dog, it is recommended to start with CREON 12 or CREON 10 which has 10,000 USP of Lipase, 37,500 USP of Protease, 33,200 USP of Amylase. There is some latitude using Creon as its effectiveness is dependent on the dog’s pH level (you do not need to test for this) so getting the exact strength is not strictly necessary.

The CREON the potency measurement comparison is as follows:

CREON 10 Composition : 150 mg Pancreatin
Amylase 8,000 PhEur units (BP Units) also equals 33,400 USP units
Lipase 10,000 PhEur units (BP Units) also equals 10,000 USP units
Protease 600 Ph Eur units (BP units) also equal 37,500 USP units

CREON 25 Composition : 300 mg Pancreatin
Amylase 18,000 PhEur units (BP Units) also equals 74,700 USP units
Lipase 25,000 PhEur units (BP Units) also equals 25,000 USP units
Protease 1,000 Ph Eur units (BP units) also equal 62,500 USP units

SINCE CREON is a human EPI drug…PLEASE SCROLL TO THE BOTTOM OF THIS PAGE TO READ MORE ABOUT CREON AND “HOW-TO” ADMINISTER. CREON can be used for both dogs and cats. With dogs, start with CREON 10 or 12. With cats, start with CREON 5 or 6



Chemist Warehouse. As of June 2019: For Creon 10,000 one bottle of 100 capsules cost $31.69 I ordered 6 bottles at a total of $190.14 plus shipping (express) $31.99 Total $222..13.  They e-mail and keep you up to date on where you meds are until they are in the U.S. You will have to sign for them when they arrive at your home.

(CREON) in Belgium… For those in the Netherlands, Belgium, or any Scandinavian country  ..


COTAZYM  (Pancrelipase) is the same as Creon


ENZYMAX TABLETS  (South America)

ENZYPLEX POWDER (Australia only) Enzyplex Powder for Dogs is an Australian made plant-based enzyme supplement for mild digestive conditions only. It is NOT a treatment for EPI and has been deregistered as a treatment for EPI from the Australian Pesticides and Veterinary Medicines Authority (APVMA) at the request of its manufacturer (de-registration date: April 2016). One of our members lodged a complaint with the Australian Consumer & Competition Commission (ACCC) against the manufacturer CEVA about the continued marketing of Enzyplex as a treatment for EPI.

It contains insufficient amounts of enzymes required for normal digestion and is not a replacement for a functional pancreas. It is not potent enough to fully address the EPI condition and over time may encourage SID/SIBO to proliferate if used in this way. If your Australian vet recommends Enzyplex for EPI in the first instance you are STRONGLY encouraged to share the APVMA deregistration advice with your vet. CREON is the recommended commercial product capable of successfully treating EPI in companion animals in Australia.

ENZYME-DIANE: GENERIC PANCREATIN (USA known source) (available in the US but can be shipped to certain countries outside of the USMany people on the EPI FORUM use these generic enzymes for a savings of anywhere between 30-50%. If you are interested in ordering bulk-priced supplemental pork-based enzymes manufactured in the US, they can be directly purchased from
*** EnzymeDiane is the ONLY enzyme company that (1)  lists EXACT enzyme potency from each batch/barrel of enzymes whereas all other enzyme companies only list that their enzymes meet the Lipase criteria of 71,400 USP units. (2) lists where her enzymes are sourced from and that the raw materials are USDA certified.***  

 (EnzyneDiane also generously donates enzymes to rescue and shelter organizations and gifts donated enzymes to those in need)
  • Pancreatin 6x10  (2 batch samples USP units
    Lipase 73,649 USP units, Protease 442,400 USP units, Amylase 512,400 USP units
    Lipase 70,840 USP units, Protease 448,000 USP units, Amylase 512,000 USP Unit.  COST (Jan 2021):  500 grams for $88, 1 kilo for $168  (shipping included)
  • Pancreatin 8x10 (1 batch sample USP units)
  • Lipase 111,720 USP units, Protease 579,600 USP units, Amylase 694,400 USP Unit.  COST:   500 grams for $108, 1 kilo for $208  (shipping included)

For Your Information:   1 kilo = 35.274 ounces
There are 357 teaspoons in a kilo of 6x since a teaspoon is 2.8 grams of powder. 

Since a teaspoon of powder is 2.8 grams ¾ tsp is 2.1 grams so 476 1 teaspoon equivalents in a kilo of 8x.  

EPIZYME8  made by V.E.T. Pharmaceuticals, 800-766-7543

EUROBIOL (available in France)

GREEN TRIPE – Raw Ground Beef Pancreas

Green Tripe is located on the west coast  (California) of USA

HARE TODAY – Raw Ground Beef Pancreas

  • Ground Beef pancreas (can be used as an alternative to pork enzymes) $2.29 per pound. Click on Raw Pet Foods and then select “Organ meats”

HAUSTIERKOFF – Raw Beef Pancreas

located in Germany  (BARF specialists since 2009) . Used by an EPI member and very satisfied with product. See forum post:

K9-KRAVING – RAW BEEF PANCREAS (available in multiple USA states)

K9-Kraving can be purchased in multiple states which dramatically saves you money on shipping costs!

LYPEX (available in England and Europe)  is an enzymatic concentrate derived from the porcine pancreas gland, available in capsules, must be opened and sprinkled on food. Do not incubate on the food. The purified and concentrated pancreatic enzymes are made into micro-pellets and each pallet is enteric-coated. This gives 100% protection to the enzymes from the damaging degradative acids present in the stomach.

Within ten minutes of the pellets passing the stomach to the alkaline environment of the small intestine the protective enteric coating dissolves and releases the protected enzymes to maximize digestion.

Many EPI dog owners who have used Lypex have found that the directions on the Lypex packaging is not sufficient. Here is one example,  “I used 4 Lypex per day. , whether it was two , three or four meals for my dog that weighed 17 kg when at her worst , to her optimum weight of 24 kg” 

Excerpt from Lypex Mfg “

Due to the enteric coating, we do not recommend premixing Lypex granules with water. Please apply the granules directly the food for consumption, as this ensures protection of the enzymes and therefore efficacy. As Lypex is tasteless, hopefully this should not affect palatability for your pet. 

Kind regards and thank you for your enquiry,
Lauren Davis
International Technical Adviser

M: + 44 (0) 7525986487
E: [email protected]

NEXTMUNE replaced  Panzyme in the UK. Must use approximately 20% more for the same efficacy as the previous product Panzyme. Nextmune: Your global partner in pet specialty pharma

PANCRE PLUS  Vet One, NDC #13985-051-77, Qty 500 pills. Mfg by NEOGEN Corp, Dist by MWI in Meridan ID 1-888-694-8381
Tablet minimum: Lipase 9000, Protease 57000, Amylase 64000, Vitamin A 1000, VitaminD3 100, VitaminE 10.
Price can vary (1000 pills for $128-$160) discuss with vet…. EPI dog usage (each dog dose may vary) crush approximately  3 pills and sprinkle on each meal.

PANCREA-TABS PLUS  by Butler Animal Health Supply NDC# 11695-1235-7
Tablet minimum: Lipase 9000, Protease 57000, Amylase 64000, Vitamin A 1000, VitaminD3 100, Vitamin E 10.
500 pills approximately $95. EPI dog usage: crush approximately (each dog dose may vary) 3 pills and sprinkle on each meal.

PANAKARE PLUS  Enzymatic concentrate derived from the porcine pancreas gland with serum concentrations of fat soluble vitamins A, E &D. made by Neogen Corp, 800-477-8201

(FOR CANADIAN CUSTOMERS:  The above mentioned company has just started a new on-line company to specifically serve the needs of Canadian clients..feel free to check out:  The Pet Pharmacy

PANCREOFLAT is an enzyme product available in India 

Pankreoflat 170 mg
22,825 USP units of amylase
6,500 USP units of lipase

Pankreoflat 170 mg: 22,825 USP units of amylase; 6,500 USP units of lipase; 25,000 USP units of protease

Pankreoflat 170 mg
22,825 USP units of amylase
6,500 USP units of lipase
25,000 USP units of protease

PANCREZYME is an enzymatic concentrate derived from the porcine pancreas gland, available in powder form. made by Virbac Animal Health, 800-338-3659

PANCREX (available in the UK)  enteric coated capsules

Pancreatin BP to provide enzymatic activity per gram not less than:

  • Free protease 1400 BP units
  • Lipase 25000 BP units
  • Amylase 30000 BP units

If so…. you need to “try” 2 level teaspoons or 2.5 level teaspoons of this powder per 1 cup of food (dry food) add in approximately 1/4 cup of warm (not hot) water….. mix and let this food, water and enzyme sit for 20 minutes… mix again and then serve. Make sure this enzyme powder is not cold (stored in the frig) it needs to be room temperature… Try this for 3-5 days and see if things (poop) is looking good…..


PANK-AID ( available in Canada

PANLIPASE  (available in India)   ..comparable to CREON

PAN-TENEX : GENERIC PANCREATIN (Unknown source). Pan-tenex™ Enzymes For Dogs | 10x Highest Potency (

PANZQUIN powdered enzymes made by Natramax with 500ug B12 included  Panzquin – Pancreatic Enzyme Concentrate from Nutramax Laboratories Veterinary Sciences, Inc.

discontinued! PANZYME made by Aristavet  (was available in the UK) Panzym Powder ( a new company Nextmune bought company out and will be selling enzymes, but must use approximately 20% more for same efficacy as previous product Panzym.

PROTEXIN  (Available in the UK )

480mg Pancreatin enteric-coated micro-pellets:

  •  Lipase  27,050 Ph. Eur. U. (minimum)
  • Amylase  22,604 Ph. Eur. U. (minimum)
  • Protease  1,325 Ph. Eur. U. (minimum)
  • Enterococcus faecium (NCIMB 10415) E1707 ? 1 x 108 CFU
  • Cyanocobalamin (Vitamin B12)  >1mg

PET-ZYMES 10X  powdered enzymes by Wonderlabs. Ships worldwide.

 No prescription needed.

Sirius Natural Pet Foods  Sirius Natural Pet Foods carries raw pancreas .

WeNzymes mfg by WePharm Wepharm | Animal Welfare | WeNzyme are enteric coated enzymes. Equivalent to LYPEX or CREON.  Available in these countries: Wepharm | Animal Welfare | Internacional : Europe, Portugal, Spain, Asia, Africa, Orient, Norway, Sweden, Finland, Israel, Romania, Bulgaria, Greece, Belgium, Czech, Cyprus

– – – – – – – – – – – – – – – – – – – – – – – – – – – – –

RAW-TO-GO Fresh raw pancreas available in the U.K. . Please ask for Lesley Osbourne, located at:

The WarehouseMarket Street
MonmouthshireNP7 5SD
Telephone: 01873 268086

VIOKASE an enzymatic concentrate derived from the porcine pancreas gland, available in powder or tablet form.  Made by Axcan Pharma, 800-950-8085

Plant Enzymes

(plant enzymes may be attempted to use for EPI dogs with severe allergies to porcine enzymes) such as:
TOTAL-ENZYMES, PROZYMES, or DR. GOODPET (preferred).   In some cases, a dog may have pork-based allergies, or meat protein allergies. If so, you may want to try an alternative plant-based enzyme. But please realize… plant enzymes are “supplements”, EPI dogs need “replacement enzymes” however, if you have to use plant enzymes because your EPI dog medically cannot tolerate pork enzymes, there have been some EPI cases (not all) that have had “temporary” success using these products. At the very least, you will need to double the recommended dose. We always advise against plant enzymes, but sometimes there are situations where porcine-based enzymes are not an option…. except….. if there is true pork allergy situation…. what we have found that does work is CREON (enteric coated enzymes). We suspect (are guessing) is that maybe becuase of the enteric coating so much less of pig enzymes are required that it doesn’t cause a reaction???!!  We do not know for sure, except to say that with every confirmed pork allergy, when given CREON, there has not been an allergic reaction and the EPI condition becomes controlled.

Additional CREON Information

IN AUSTRALIA There are four varying strengths of CREON® available in Australia – 5,000, 10,000, 25,000 and 40,000. What is recommended as a starting point is to use one Creon 10,000 per meal (not per cup as recommended with porcine pancreatic powders only available overseas), except for miniature dogs in which case you might want to start with half the contents of one Creon 10,000 capsule.  Creon 10,000 and less available without a prescription from all pharmacies. Creon 25,000 and greater is only available with a prescription issued by your vet. You may then choose to have the prescription filled at a discount pharmacy. If you are in Australia, please read the regularly updated EPI Management for Australian Dogs brochure on the Brochures outside of USA page. Note: In October 2015, we became aware of another prescription pancreatin product called PANZYTRAT® 25,000 that is almost identical to Creon 25 000. This may also be an option (more information as it comes to hand).

If you decide on pancreatin CREON capsules (please share with your vet!):
For a much discounted CREON you can try either: or or