- USP = United States Pharmacopeia
- BP = British Pharmacopoeial
- FIP = Fédération Internationale Pharmaceutique
- PhEur = European Pharmacopoeia
Conversion from FIP/PhEur units to USP units as follows:
- for lipase, 1 FIP/PhEur unit = 1 USP unit;
- for amylase, 1 FIP/PhEur unit = 4.15 USP units;
- for protease, 1 FIP/PhEur unit = 62.5 USP units
- for lipase, 1BP/PhEur unit = 1 USP unit;
- for amylase, 1 BP/PhEur unit = 4.15 USP units;
- for protease, 1 BP/PhEur unit = 62.5 USP units
information taken from : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462091/ and they got THEIR information from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462091/#i1551-6776-12-2-115-b33 Also….. VERY IMPORTANT….. is that the enzyme potency amount required also depends on how the product is compounded and what format it is manufactured in. The type of enzyme product determines how quickly it will be used in the digestive system so consequently this determines how potent it needs to be.
The various type of enzyme products are:
powder,
granules,
enteric coated granules,
tablets,
capsules with enteric coated spheres
- The units of the enzymes in enteric coated products (such as CREON) are vastly less – – then the powders/tablets due to the fact that the majority of the potency of enteric coated products reach the digestive system in it’s entirety, whereas powders/tablets potency can often be up to 70% destroyed by pH levels in the digestive tract- -before the enzymes can reach the small intestine.
- On the flip side, the powders/tablets are better absorbed due to the size of the powder/dissolved tablet grains vs. the enteric coated pellets.
- CREON (enteric coated pellets in capsules) are designed for human consumption and are processed to be effective in the human digestive system. The pH level in the human digestive tract is approximately 4 where as the pH level in the canine digestive tract is approximately 1. Because of this variance in pH levels, we as pet owners need to adjust the CREON administration timing technique to try and figure out how best to administer the CREON to our pets to achieve optimal digestion.
To see how enzymes work with food in the body, please click on the CREON link and watch this excellent CREON action video :
https://www.creonhcp.com/mechanism-of-action
Chemeyes, LLC in the UK ( Canine enzyme products in the UK) http://www.chemeyes.co.uk/
The Chemeyes porcine pancreatic enzyme strength is as follows:
To further accommodate EPI customers, a running updated enzyme “certificate of analysis” will be posted on the Chemeyes website for each batch of enzymes.
Not only is this a good substitute for Tryplase, it also will interest those people in the UK that formerly used the Vet V powder and now use pancreatin powder. The powder is sold and pre-packed like Tryplase or as a powder. The costs are as follows and they are significantly lower than the comparable products in the powder format:
Capsules
50 capsules – £ 16
100 capsules – £ 18
250 capsules – £ 42
500 capsules – £ 78
Powder
50 grams – £ 12
250 grams – £ 40
500 grams – £ 85
1 kg – £ 150
5kg – £ 450
The pancreatin powder which appears to be the replacement for the Vet V powder is only 15,000 Lipase but costs out at 22p per gram whereas the 250 gram tub of Chemeyes costs in at 16p per gram on a stronger product.
The details of the Chemeyes product will now be included in the “Managing EPI in the UK” brochure which is included in the download section of this website.
This powdered enzyme product can also be exported to the EU and India which will hopefully be another option for our fellow members.To contact Cameron or Suj directly, write to: [email protected]
The company’s website is: http://www.chemeyes.co.uk/
European Enzyme products potency guide
Pancrex Granules (1g=1ml)
Pancreatin BP to provide enzymatic activity per gram not less than:
Free protease 300 BP units (5ml = 1500)
Lipase 5000 BP units (5ml = 25000)
Amylase 4000 BP units (5ml = 20000)
Lypex
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease 1200 BP units
Lipase 30000 BP units
Amylase 18750 BP units
Panzym (1g= 1ml)
Pancreatin BP to provide enzymatic activity per gram not less than:
Free protease 2100 BP units
Lipase 38000 BP units
Amylase 32500 BP units
Pancrex V Capsules
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease 430 BP units
Lipase 8000 BP units
Amylase 9000 BP units
Pancrex V Capsules 125 mg
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease 160 BP units
Lipase 2950 BP units
Amylase 3300 BP units
Pancrex V Forte Tablets
Pancreatin BP to provide enzymatic activity per tablet not less than:
Free protease 330 BP units
Lipase 5600 BP units
Amylase 5000 BP units
Tryplase
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease 450 BP units
Lipase 13000 BP units
Amylase 9000 BP units
(older) Creon 10
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease 600 BP units
Lipase 10000 BP units
Amylase 8000 BP units
(newer) Creon 12 – delayed activity
Pancreatin BP to provide enzymatic activity per capsule not less than:
Protease 38000 BP units
Lipase 12000 BP units
Amylase 60000 BP units
Creon 25
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease 1000 BP units
Lipase 25000 BP units
Amylase 18000 BP units
Creon 300 mg
(excerpt from VINMEC INT’L HOSPITAL : https://www.vinmec.com/eng/article/creon-ingredients-uses-dosage-and-side-effects-en
” Each Creon capsule contains 300mg of Pancreatin (pancreatin powder, prepared from the pancreatic tissue of pigs, containing digestive enzymes in the pancreas, corresponding to 18000 units of amylase, 25000 units of lipase, 1000 units of insulin”