Select Page
Enzyme Conversions
  • USP = United States Pharmacopeia
  • BP = British Pharmacopoeial
  • FIP = Fédération Internationale Pharmaceutique
  • PhEur = European Pharmacopoeia

Conversion from FIP/PhEur units to USP units as follows:

  • for lipase, 1 FIP/PhEur unit = 1 USP unit;
  • for amylase, 1 FIP/PhEur unit = 4.15 USP units;
  • for protease, 1 FIP/PhEur unit = 62.5 USP units
  • for lipase, 1BP/PhEur unit = 1 USP unit;
  • for amylase, 1 BP/PhEur unit = 4.15 USP units;
  • for protease, 1 BP/PhEur unit = 62.5 USP units

information taken from : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462091/  and they got THEIR information from  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462091/#i1551-6776-12-2-115-b33  Also….. VERY IMPORTANT….. is that the enzyme potency amount required also depends on how the product is compounded and what format it is manufactured in. The type of enzyme product determines how quickly it will be used in the digestive system so consequently this determines how potent it needs to be.

The various type of enzyme products are:

powder,
granules,
enteric coated granules,
tablets,
capsules with enteric coated spheres

  • The units of the enzymes in enteric coated products (such as CREON) are vastly less – – then the powders/tablets due to the fact that the majority of the potency of enteric coated products reach the digestive system in it’s entirety, whereas powders/tablets potency can often be up to 70% destroyed by pH levels in the digestive tract- -before the enzymes can reach the small intestine.
  • On the flip side, the powders/tablets are better absorbed due to the size of the powder/dissolved tablet grains vs. the enteric coated pellets.
  • CREON (enteric coated pellets in capsules) are designed for human consumption and are processed to be effective in the human digestive system.  The pH level in the human digestive tract is approximately 4 where as the pH level in the canine digestive tract is approximately 1.  Because of this variance in pH levels, we as pet owners need to adjust the CREON administration timing technique to try and figure out how best to administer the CREON to our pets to achieve optimal digestion.

To see how enzymes work with food in the body, please click on the CREON link and watch this excellent CREON action video  :
https://www.creonhcp.com/mechanism-of-action

 

 

Chemeyes, LLC in the UK ( Canine enzyme products in the UK) http://www.chemeyes.co.uk/

Updated May 8, 2025 with higher strength enzymes: The Chemeyes porcine pancreatic enzyme strength is as follows:

Lipase 34,000  BP units
Protease 2,400  BP units
Amylase 29,400  BP units
 
To convert Chemeyes BP porcine pancreatin powder potency to USP units porcine pancreatin powder potency is as follows:
 
Lipase 34,000  BP units = 34,000 USP units of Lipase
Protease 2,400  BP units = 150,000 USP units of Protease
Amylase 29,400  BP units = 122,010 USP units of Amylase
 
According to the chemist at Chemeyes, LLC regarding dosage:
They recommend a starting point of 1 capsule or 1/4 teaspoon (both are 0.5g) per 100g (1/2 cup) of food. They generally get good feedback from this but sometimes there’s a need to increase to 2 capsules / 1 gram.
 
Based on this…. Epi4Dogs suggests either following Chemeyes dosing instructions  and increase if needed……
OR
Do what we tend to recommend in the USA, start with a heavier dose in the beginning (in this case with Chemeyes enzyme products it would mean double the dose temporarily) and once the dog has been delivering normal looking poos for about a month… THEN reduce the dose.
 

To contact Cameron or Suj directly, write to:   [email protected] 
The company’s website is:   http://www.chemeyes.co.uk/

 

European Enzyme products potency guide

Pancrex Granules (1g=1ml)
Pancreatin BP to provide enzymatic activity per gram not less than:
Free protease             300 BP units (5ml = 1500)
Lipase                        5000  BP units (5ml = 25000)
Amylase                     4000 BP units (5ml = 20000)

Lypex
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease               1200 BP units
Lipase                          30000 BP units
Amylase                       18750 BP units

Panzym (1g= 1ml)
Pancreatin BP to provide enzymatic activity per gram not less than:
Free protease                2100 BP units
Lipase                           38000 BP units
Amylase                        32500 BP units

Pancrex V Capsules
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease                 430 BP units
Lipase                            8000 BP units
Amylase                         9000 BP units

Pancrex V Capsules 125 mg
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease                 160 BP units
Lipase                            2950 BP units
Amylase                         3300 BP units

Pancrex V Forte Tablets
Pancreatin BP to provide enzymatic activity per tablet not less than:
Free protease                  330 BP units
Lipase                             5600 BP units
Amylase                          5000 BP units

Tryplase
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease                  450 BP units
Lipase                             13000 BP units
Amylase                          9000 BP units

(older) Creon 10
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease                  600 BP units
Lipase                             10000 BP units
Amylase                          8000 BP units

(newer) Creon 12 – delayed activity
Pancreatin BP to provide enzymatic activity per capsule not less than:
Protease                           38000 BP units
Lipase                             12000 BP units
Amylase                          60000 BP units

Creon 25
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease                  1000 BP units
Lipase                             25000 BP units
Amylase                          18000 BP units

Creon 300 mg
(excerpt from VINMEC INT’L HOSPITAL : https://www.vinmec.com/eng/article/creon-ingredients-uses-dosage-and-side-effects-en
” Each Creon capsule contains 300mg of Pancreatin (pancreatin powder, prepared from the pancreatic tissue of pigs, containing digestive enzymes in the pancreas, corresponding to 18000 units of amylase, 25000 units of lipase, 1000 units of insulin”