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Vitamin B12, (cobalamin), is a water-soluble vitamin. Animals do not store it in their bodies but excrete excess amounts through urination.  B12 has a key role in the normal functioning of the brain and nervous system via the synthesis of myelin(myelinogenesis)[1][2], and the formation of red blood cells…  so a dog needs adequate amounts of this vitamin for the proper functioning of his nervous system and normal cell development. B12 is one of eight B vitamins. It is involved in the metabolism of every cell of the human body, especially affecting DNA synthesis, fatty acid and amino acid metabolism.[3] No fungi, plants, or animals (including humans) are capable of producing vitamin B12. Only bacteria and archaeahave the enzymes needed for its synthesis. Some substantial sources of B12 include animal products (shellfish, meat), fortified food products, and dietary supplements.[4][5]B12 is the largest and most structurally complicated vitamin and can be produced industrially through bacterial fermentation synthesis, typically used to manufacture B12 for fortified foods and supplements. It can also be produced synthetically via vitamin B12 total synthesis.

If your dog shows any signs of lethargy, loss of appetite and depression please take your dog to the vet for a diagnosis. If your dog has EPI, be sure to check the B12 level, as insufficient B12 levels often is a problem in EPI pets. IN dogs over 80% of all EPI dogs will need B12 supplementation and virtually all cats with EPI will need B12 supplementation.

The difference B12 can make ……

The below is an actual chart of Seth’s EPI dog, “Donna”   …. that visually shows the amazing difference B12 can make in an EPI dog that did not have optimal B12 levels.  Thank you Seth for sharing this with us!

3/26/2013 – 2nd B12 shot – 53 lbs

4/2/2013 – 3rd B12 shot – 56.8 lbs

4/10/2013 – 4th B12 shot – 58.9 lbs

4/17/2013 – 5th B12 shot – 60 lbs

4/22/2013 – 2 cups a meal, 2 times a day. (my vet recommended we only feed her twice a day since she gained back almost 20 lbs :))

5/15/2013 – 6th B12 shot – 63.8 lbs

6/27/2013 – 7th B12 shot – 64.5 lbs 

9/1/2013 – Her stool was not looking good so based on the advice of everybody here, I started her on the Tylan again. I will include it in her meal for 45 days.

9/4/2013 – 64 lbs

11/7/2013 – 60 lbs. Her stool went back to normal. I think the Tylan for 45 days was successful. :)