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Enzymatic Activity  

In humans ..Pancreatic enzyme secretion increases rapidly in response to a meal up to 6-fold above inter-digestive levels and reaches maximal values within 20?60 min post-prandially (after a meal).12 Enzyme output decreases thereafter to a 3- to 4-fold sustained increase, which is maintained for 3 to 4 hours before returning to inter-digestive levels. This post-prandial pattern means that a maximal output of 3000-6000 IU/min lipase and a mean output of 2000-4000 IU/min lipase occur after ingestion of a normal mixed meal in healthy subjects.12 Enzyme substitution therapy should be able to mimic this pattern in situations of pancreatic exocrine insufficiency. (cited by J Enrique Domínguez-Muñoz “EPI Diagnosis & Treatment”, Feb 16, 2011) .

Because a dog’s digestive system is slightly different than a humans, we estimate that approximately 1-2 hours after an enzymed meal the inter-digestive levels return to normal.

Excellent video of enzymatic activity (in a human… but still an excellent video put out by CREON!)
Click on the “Scroll to learn more” arrow on the following page: https://www.creon.com/hcp/mechanism-of-action