Tick & Flea Meds Analysis 5-2020

Epi4Dogs Foundation Inc.’s mission is the advancement of science and education relating to EPI (Exocrine Pancreatic Insufficiency), yielding useful insights and positive outcomes in better managing EPI in dogs and cats. Our goals are to support and/or collaborate with veterinary EPI research and researchers, and to promote EPI awareness by educating the general public, pet owners, pet organizations, rescue and shelter organizations, veterinary schools and veterinarians.
Tuckaboo Pam
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Posts: 1346
Country: United States
State: Florida
Pet name: Tucker
My name: Pam H.

Re: Tick & Flea Meds Analysis 5-2020

Post by Tuckaboo Pam » 22 Dec 2022, 07:51

I get a picture of a cute puppy & the page is not here message. Using my laptop. Is there anything about Revolution in the article?
Tucker was a shepherd/lab mix--- TLI 1.3, Folate 9.7, Cobalamin 666, Lipase 38. Took Diane's Enzymes 4 teaspoons/day, Wonderlabs B12 one capsule per day, and Tylan 1/16 teaspoon/ morning (to hold SID at bay). Taste of the Wild High Prairie, 1 1/2 cups/day, with a total of 4 cups of Fresh Pet. Stopped eating everything in sight, and went from 60 to 85 pounds! Tucker was my boyfriend, and my husband was OK with that. Tucker succumbed to hemangiosarcoma, but we cherished every day we had with that wonderful, beautiful boy. I will always, always miss my sweet big boy.

Tuckaboo Pam
Member
Posts: 1346
Country: United States
State: Florida
Pet name: Tucker
My name: Pam H.

Re: Tick & Flea Meds Analysis 5-2020

Post by Tuckaboo Pam » 23 Dec 2022, 18:13

Did anyone read the article and remember whether Revolution is mentioned? I still get the page not found message. Revolution protects against fleas & heartworms, + some other parasites. It is a topical treatment. Thanks---Pam
Tucker was a shepherd/lab mix--- TLI 1.3, Folate 9.7, Cobalamin 666, Lipase 38. Took Diane's Enzymes 4 teaspoons/day, Wonderlabs B12 one capsule per day, and Tylan 1/16 teaspoon/ morning (to hold SID at bay). Taste of the Wild High Prairie, 1 1/2 cups/day, with a total of 4 cups of Fresh Pet. Stopped eating everything in sight, and went from 60 to 85 pounds! Tucker was my boyfriend, and my husband was OK with that. Tucker succumbed to hemangiosarcoma, but we cherished every day we had with that wonderful, beautiful boy. I will always, always miss my sweet big boy.

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Olesia711
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Location: North Carolina
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Pet name: Izzy
My name: olesia

Re: Tick & Flea Meds Analysis 5-2020

Post by Olesia711 » 23 Dec 2022, 19:51

Yes, Revolution Plus has been added to the list. SInce you are having trouble reading the Aug 2020 Jake Tick & Flea report, i am copying and pasting here (below).... HOWEVER.... if you want to read the full report which would be best cause it better explains things.......just click on the June 2020 and the 13 pages that are already uploaded, well worth the read as it more thoroughly explains things.

AUG 2020: On September 20, 2018, the United States Food and Drug Administration (FDA) issued a warning that the following flea and tick medications have caused adverse events in dogs and cats such as muscle tremors, ataxia and seizures:

Bravecto (fluralaner) tablets for dogs;
Bravecto (fluralaner) topical solution for cats and dogs;
Nexgard (afoxalaner) tablets for dogs; and,
Simparica (sarolaner) and Simparica Trio (sarolaner/moxidectin/pyrantel) tablets for dogs.
All of these medications are in the isoxazoline class of compounds. Isoxazoline is a parasiticide.

The FDA worked with manufacturers of isoxazoline products to include new label information to highlight neurologic events because these events were seen consistently across the isoxazoline class of products.

Two additional drugs that are also in the isoxazoline class had recently received FDA approval and carry the warning on their labels:

Credelio (lotilaner) tablets for dogs; and,
Revolution Plus (selamectin and sarolaner topical solution) for dogs and cats.
Isoxazoline class flea and tick medications should not be confused with spinosads – a natural substance made by a soil bacterium that can be toxic to insects – that is also for treatment or prevention of fleas. Two of the most well-known spinosad products are Trifexis® and Comfortis®. Dogs that are epileptic or prone to seizures should not be given spinosad.

Comparatively, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the findings that prompted the FDA warning about the isoxazoline class.

Coinciding with the warning, Project Jake had just wrapped up its online questionnaire about flea and tick medications to 2,751 respondents on August 21, 2018, and released its findings on June 2, 2020.

So why release the results if the FDA already issued the warning?

The Project Jake Survey was more broadly based and included:

companion pet caregivers who did not give their pets any flea or tick medications;
pet caregivers who did not see any adverse reactions as well as those that did report them, providing a more inclusive review of isoxazoline use;
observations by pet caregivers pre‐ (3 months) and post‐drug use;
questions when adverse event occurred after use of the drug;
questioned about number of doses of drug(s) given before an adverse event;
other concurrent health issues and treatments given were requested;
multiple adverse events were listed for each report; and,
recovery information and/or follow‐ups were included.
Remember, this survey also concluded before the FDA warning was released, so it represented an objective review as there was ongoing discussion and research being conducted prior to the release.

Additionally, the FDA reporting system depends on the voluntary reporting of adverse clinical events by veterinarians and animal caregiver/owners, as well as the mandatory reporting of adverse events by manufacturers. This FDA information is valuable, even if some of the FDA reports could be duplicates.

Out of the 2,751 respondents:

Gave their dog any flea treatment: 1,594 (57.9%)
Gave their dog an isoxazoline treatment: 1,325 (48.2%)
Did the dog experience a reaction to any treatment?
Yes 1,062 (66.6%)
No 576 (36.1%)
Unsure 130 (8.2%)
To find out the rest of the results and comparative data with the FDA’s database, you can read Project Jake’s peer-reviewed and open-access paper, “Survey of canine use and safety of isoxazoline parasiticides”.

About Project Jake: The survey group included Valerie Palmieri, W. Jean Dodds, Judy Morgan, Elizabeth Carney, Herbert A. Fritsche, Jaclyn Jeffrey, Rowan Bullock, and Jon P. Kimball.

MY PERSONAL TAKE AWAY IS TO BEST GIVE HEARTWORM AND TICK AND FLEA MEDS SEPARATELY TO ANY DOG THAT HAS A MEDICAL CONDITION.... AND TO STICK WITH THE MONTHLY TOPICALS VS. LESS FREQUENT (MORE POTENT) TICK AND FLEA MEDS..............
Olesia, was owned by Izzy, a 35lb Spanish Water Dog (SWD), Diagnosed at 1.5 years old - TLI results 1.. Izzy passed away on February 13, 2020 at 15 years old. She lived with EPI for 13+1/2 years. It was because of Izzy that Epi4Dogs was started... she was the inspiration. May her legacy of helping others with EPI continue for as long as needed.........

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